Latest News

Congratulations, Dr. Patricia Lang!

Posted on October 24, 2016

Patricia successfully defended her PhD thesis entitled 'Identification and characterization of new factors in the framework of Arabidopsis thaliana miRNA function' read more

Congratulations, Patricia!

Congratulations! Detlef receiving honorary doctorate from ...

Posted on October 07, 2016

... Swedish University of Agriculture read more

Farewell to Patrick

Posted on September 30, 2016

Patrick just completed his Diploma thesis entitled ‘Specificity and natural variation in response to allelochemicals’. read more

He will soon move on to start a PhD with Claude Becker at the GMI in Vienna

Good luck!

ACD6 dependent hybrid necrosis in local populations

Posted on September 05, 2016

Novel allelic variants in ACD6 cause hybrid necrosis in local collection of Arabidopsis thaliana read more

Swiadek M, Proost S, Sieh D, Yu J, Todesco M, Jorzig C, Rodriguez Cubillos AE, Plötner B, Nikoloski Z, Chae E, Giavalisco P, Fischer A, Schröder F, Kim ST, Weigel D, Laitinen RA

Hybrid necrosis is a common type of hybrid incompatibility in plants. This phenomenon is caused by deleterious epistatic interactions, resulting in spontaneous activation of plant defenses associated with leaf necrosis, stunted growth and reduced fertility in hybrids. Specific combinations of alleles of ACCELERATED CELL DEATH 6 (ACD6) have been shown to be a common cause of hybrid necrosis in Arabidopsis thaliana. Increased ACD6 activity confers broad-spectrum resistance against biotrophic pathogens but reduces biomass production. We generated 996 crosses among individuals derived from a single collection area around Tübingen (Germany) and screened them for hybrid necrosis. Necrotic hybrids were further investigated by genetic linkage, amiRNA silencing, genomic complementation and metabolic profiling. Restriction site associated DNA (RAD)-sequencing was used to understand genetic diversity in the collection sites containing necrosis-inducing alleles. Novel combinations of ACD6 alleles found in neighbouring stands were found to activate the A. thaliana immune system. In contrast to what we observed in controlled conditions, necrotic hybrids did not show reduced fitness in the field. Metabolic profiling revealed changes associated with the activation of the immune system in ACD6-dependent hybrid necrosis. This study expands our current understanding of the active role of ACD6 in mediating trade-offs between defense responses and growth in A.  thaliana.

Farewell to Ezgi and Jorge

Posted on August 31, 2016

We’re saying goodbye to Ezgi and Jorge - all the best for their new adventures! read more

Ezgi will start a PhD with former Weigelworld postdoc Chang Liu at the ZMBP in Tübingen, and Jorge will move to Leipzig and join Barbara Treutlein’s lab at MPI-EVA as a postdoc.

Graduation and farewell party!

Posted on August 08, 2016

On July 29, we said goodbye to George Wang, who will be heading the Computomics Corporation in Davis, CA. And .... read more

We also celebrated the three freshly minted PhD graduates, Diep Tran (starting as a postdoc with Lionel Navarro at the ENS in Paris), Jorge Kageyama (starting as a postdoc with Barbara Treutlein at the MPI-EVA in Leipzig) and Cris Zaidem (starting in 2017 as a postdoc with Michael Purugganan at NYU)




Upcoming Events


Kinderuni am Heidengraben - Lecture for kids

October 29, 3 pm
Volksbank Reutlingen

Detlef talking about evolution (in German)
Warum ist der Schäferhund kein Dackel?


MiKo Talk Tom Mitchell-Olds


Meeting StEvE