Latest News

Detlef to receive Novozymes Prize

Posted on February 21, 2020

Lifetime achievement award comes with 3 million kr read more

"The 2020 Novozymes Prize is being awarded to Professor Detlef Weigel (photo) for his outstanding research contributions that have led to groundbreaking new knowledge of the genetic structure of plants. His work has had major impact on developing innovative biotechnological solutions for crop improvement and understanding how plants adapt to the environment. The Novo Nordisk Foundation awards the Prize, which is accompanied by DKK 3 million."

Congratulations Moi!: Award of the American Society of Naturalists

Posted on February 13, 2020

Moises Exposito-Alonso received 2020 Jasper Loftus-Hills Young Investigator Award of the American Society of Naturalists read more

The American Society of Naturalist's Young Investigator Award  goes to applicants who completed their PhD three years preceding the application deadline or are in their last year of a PhD program.

PhD studentship applications open!

Posted on January 28, 2020

Deadline for next IMPRS round: February 29, 2020 read more

International Max Planck Planck Research School (IMPRS) "From Molecules to Organisms"

Talented junior scientists are offered the opportunity to earn a doctorate under excellent research conditions in Tübingen.  Fully-funded projects are offered at the Max Planck Institute for Developmental Biology, the Friedrich Miescher Laboratory and the University of Tübingen, alongside a structured supporting program. The working language of our school is English.

WeigelWorld is currently seeking students interested in long-read assemblies and the functional analysis of plant microbes and microbiomes.

Apply now!

 

 

 

Commentary on Earth Biogenome project

Posted on December 01, 2019

Please take genome assembly quality into account read more

The Earth BioGenome project: Opportunities and Challenges for Plant Genomics and Conservation

Moises Exposito Alonso, Hajk Georg Drost, Hernán A. Burbano & Detlef Weigel
Plant Journal | 01 December 2019 https://doi.org/10.1111/tpj.14631

Sequencing them all. That is the ambitious goal of the recently launched Earth BioGenome Project (Lewin et al., 2018), which aims to produce reference genomes for all eukaryotic species within the next decade. In this Perspective, we discuss the opportunities of this project with a plant focus, but highlight also potential limitations. This includes the question of how to best capture all plant diversity, as the green taxon is one of the most complex clades in the tree of life, with over 300,000 species. For this, we highlight four key points: (1) the unique biological insights that could be gained from studying plants, (2) their apparent underrepresentation in sequencing efforts given the number of threatened species, (3) the necessity of phylogenomic methods that are aware of differences in genome complexity and quality, and (4) the accounting for within?species genetic diversity and the historical aspect of conservation genetics.

AraPheno and AraGWAS updates

Posted on November 19, 2019

RNA-Seq and knockout mutation data for Arabidopsis thaliana read more

AraPheno and the AraGWAS Catalog 2020: a major database update including RNA-Seq and knockout mutation data for Arabidopsis thaliana

Matteo Togninalli, Ümit Seren, Jan A Freudenthal, J Grey Monroe, Dazhe Meng, Magnus Nordborg, Detlef Weigel, Karsten Borgwardt, Arthur Korte, Dominik G Grimm

Nucleic Acids Research, gkz925, https://doi.org/10.1093/nar/gkz925

Genome-wide association studies (GWAS) are integral for studying genotype-phenotype relationships and gaining a deeper understanding of the genetic architecture underlying trait variation. A plethora of genetic associations between distinct loci and various traits have been successfully discovered and published for the model plant Arabidopsis thaliana. This success and the free availability of full genomes and phenotypic data for more than 1,000 different natural inbred lines led to the development of several data repositories. AraPheno (https://arapheno.1001genomes.org) serves as a central repository of population-scale phenotypes in A. thaliana, while the AraGWAS Catalog (https://aragwas.1001genomes.org) provides a publicly available, manually curated and standardized collection of marker-trait associations for all available phenotypes from AraPheno. In this major update, we introduce the next generation of both platforms, including new data, features and tools. We included novel results on associations between knockout-mutations and all AraPheno traits. Furthermore, AraPheno has been extended to display RNA-Seq data for hundreds of accessions, providing expression information for over 28 000 genes for these accessions. All data, including the imputed genotype matrix used for GWAS, are easily downloadable via the respective databases.

bioRxiv: Microbial biomass & disease in wild plants

Posted on November 03, 2019

Absolute microbial biomass as an indicator of disease in wild A. thaliana read more

The relationship between microbial biomass and disease in the Arabidopsis thaliana phyllosphere

Karasov et al., bioRxiv 828814, posted November 3, 2019.

A central goal in microbiome research is to learn what distinguishes a healthy from a dysbiotic microbial community. Shifts in diversity and taxonomic composition are important indicators of dysbiosis, but a full understanding also requires knowledge of absolute microbial biomass. Simultaneous information on both microbiome composition and the quantity of its components can provide insight into microbiome function and disease state. Here we use shotgun metagenomics to simultaneously assess microbiome composition and microbial load in the phyllosphere of wild populations of the plant Arabidopsis thaliana. We find that wild plants vary substantially in the load of colonizing microbes, and that high loads are typically associated with the proliferation of single taxa, with only a few putatively pathogenic taxa achieving high abundances in the field. Our results suggest (i) that the inside of a plant leaf is on average sparsely colonized with an estimated two bacterial genomes per plant genome and an order of magnitude fewer eukaryotic microbial genomes, and (ii) that higher levels of microbial biomass often indicate successful colonization by pathogens. Lastly, our results show that load is a significant explanatory variable for loss of estimated Shannon diversity in phyllosphere microbiomes, implying that reduced diversity may be a significant predictor of microbial dysbiosis in a plant leaf.

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Upcoming Events

Mar
01

EMBO/EMBL Symposium: The Organism and its Environment

March 1-4
EMBL Heidelberg

Detlef as Keynote speaker about "Epistasis, the spice of life: Lessons from the study of the plant immune system"


Mar
03

Weed Science Society of America 2020 Annual Meeting

March 2-5
Hawaii, USA

Bridgit speaking about "The Evolutionary Genomics of Herbicide-Resistant Weeds".


Mar
04

MiKo Talk Michaela Frye

MPH Lecture Hall, 3 pm

Title: "TBA"