G3: Plant genetic archaeology: Pedigree of a trisomic line

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Whole-Genome Sequencing Reveals the Pedigree of a Classical Trisomic Line

Patrice A. Salomé and Detlef Weigel

The circadian oscillator is astonishingly robust, to changes in the environment, but also to genomic changes that alter the copy number of its components … Read the rest

PLoS Genet: Hybrid incom- patibility & R gene evolution

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Analysis of a Plant Complex Resistance Gene Locus Underlying Immune-Related Hybrid Incompatibility and Its Occurrence in Nature

From collaboration with Alcázar, Koornneef and Parker labs:

Rubén Alcázar,  Marcel von Reth, Jaqueline Bautor, Eunyoung Chae, Detlef Weigel, Maarten Koornneef, Jane E. … Read the rest

Current Biology:

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miRNA networks & leaf complexity

Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes

Ignacio Rubio-Somoza, Chuan-Miao Zhou, Ana Confraria, Claudia Martinho, Patrick von Born, Elena Baena-Gonzalez, Jia-Wei Wang, Detlef Weigel

Current Biology 24, 2714–2719

Highlights

•miR319-targeted TCPs … Read the rest

Cell: NLRs as hotspots of deleterious epistasis

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Species-wide Genetic Incompatibility Analysis Identifies Immune Genes as Hot Spots of Deleterious Epistasis

Species-wide Genetic Incompatibility Analysis Identifies Immune Genes as Hot Spots of Deleterious Epistasis

Eunyoung Chae, Kirsten Bomblies, Sang-Tae Kim, Darya Karelina, Maricris Zaidem, Stephan Ossowski, Carmen Martín-Pizarro, … Read the rest

PLoS Genet: Evolution of DNA Methylation Patterns

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Evolution of DNA Methylation Patterns in the Brassicaceae is Driven by Differences in Genome Organization

Danelle K. Seymour, Daniel Koenig, Jörg Hagmann, Claude Becker, Detlef Weigel

PLoS Genetics Published: November 13, 2014; DOI: 10.1371/journal.pgen.1004785

DNA methylation is an ancient molecular … Read the rest

Genome Res: Hi-res Hi-C analysis in Arabidopsis

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Genome Res. 2014 Nov 3. pii: gr.170332.113.

Genome-wide analysis of local chromatin packing in Arabidopsis thaliana.

Wang C, Liu C, Roqueiro D, Grimm D, Schwab R, Becker C, Lanz C, Weigel D.

Genome Res. 2014 Nov 3. pii: gr.170332.113.

The … Read the rest

CHM: Convergence of pathogens on common host proteins

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Weßling R et al.: Convergent targeting of a common host protein-network by pathogen effectors from three kingdoms of life.

We were able to contribute analyses based on 1001 Genomes data to his exciting project describing how a common set of … Read the rest

SPP1529 Adaptomics projects renewed

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Our two projects in the SPP1529 (Research Focus Program of the German Research Council DFG) have been renewed

One on variation in Capsella, with Magnus Nordborg and Barbara Neuffer, and one on adaptation of various Brassicaceae along a steep rainfall … Read the rest

Dissection of miRNA pathways using protoplasts

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Mol Plant. 2014 Oct 24. pii: ssu119. [Epub ahead of print]

Dissection of miRNA pathways using Arabidopsis mesophyll protoplasts.

Martinho C, Confraria A, Elias CA, Crozet P, Rubio-Somoza I, Weigel D, Baena-González E.

microRNAs (miRNAs) control gene expression mostly post-transcriptionally … Read the rest

Trowel: superior error correction module for Illumina

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Trowel: a fast and accurate error correction module for Illumina sequencing reads.
Lim EC, Müller J, Hagmann J, Henz SR, Kim ST, Weigel D.
Bioinformatics. 2014 Jul 29. pii: btu513. [Epub ahead of print]

MOTIVATION:
The ability to accurately read … Read the rest