Identify an EMS lesion in one week–SHOREmap paper published!

Traditional strategies for identification of causal mutations involve two discrete steps: recombinant genotyping and candidate gene sequencing.

To dramatically speed up identification of causative point mutations and small deletions, we provide the software package SHOREmap (http://1001genomes.org/downloads/shore.html), an extension of the short read analysis pipeline SHORE. SHOREmap supports genome-wide genotyping and candidate-gene sequencing in a single step through analysis of deep sequencing data from a large pool of recombinants.

Schneeberger, K, Ossowski, S, Lanz, C, Juul, T, Petersen, AH, Nielsen, KL, Jorgensen, J, Weigel, D, and Andersen, SU (2009).
SHOREmap: simultaneous mapping and mutation identification by deep sequencing.
Nat Methods, 6(8):550-1.